RNA Details
Disease Name
diabetic cardiomyopathy
Tissue
heart
RNA Symbol
KLK8
RNA ID
11202
RNA Type
mRNA
Alteration Pattern
up regulation
Species
homo sapiens
Detection Methods
NA
Target
NA
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
33754057
Title
A novel role of kallikrein-related peptidase 8 in the pathogenesis of diabetic cardiac fibrosis
Year
2021
Function
"KLK8 overexpression led to plakoglobin-dependent association of p53 with hypoxia inducible factor (HIF)-1alpha, which further enhanced the transactivation effect of HIF-1alpha on the TGF-beta1 promoter. KLK8 also induced the binding of p53 with Smad3, subsequently promoting pro-EndMT reprogramming via the TGF-beta1/Smad signaling pathway in human coronary artery endothelial cells."